Coming 20 years after the release of the first draft of the Human Genome (1), the HUPO Human Proteome Project (HPP) celebrated its 10th Anniversary, following a number of major achievements, with the publication of the first high stringency blueprint of the human proteome in 2020 describing the detection of 90.4% of all predicted human proteins (2) which increased to 92.8% in 2021 (3). This was due, in part, by significant advances in key technologies and multiple efforts by international consortia.
With these unprecedented developments providing rich volumes of data and an extensive toolbox with which to interrogate the proteome, the focus is now turning to an understanding of individual protein function and clinical translation which will aid the rollout of precision/personalized medicine (4). To assist this the HUPO has recently announced the HPP Grand Project which will focus on the exploration of the human proteome by understanding proteins in their network environment and will enable the elucidation of its biological significance.
In this presentation I will outline the current status of the human proteome, describe some of the emerging enabling technologies and detail the HPP Grand Project.