Poster Presentation 14th Australian Peptide Conference 2022

Photo dynamic activity of short peptide (#103)

Karrar Al Taief 1 , Stephanie Nemec 2 , Elvis Pandzic 3 , Pall Thordarson 1 , Kristopher Kilian 1
  1. School of Chemistry , UNSW, Sydney, NSW, Australia
  2. School of Materials Science and Engineering, UNSW, Sydney, NSW, Australia
  3. Bio-medical Imaging Facility , University of New South Wales , Sydney , NSW, Australia

Abstract

The stimuli responsive molecules have attracted significant attention due to non-invasive manipulation. Such system requires compatibility between stimuli (pH, temperature, solution) and the molecule Light though, is the most attractive stimuli in controlling the molecule spatially and temporally. The process of "photo responsiveness “requires both a particular wavelength and specifically designed molecule that respond to the corresponding wavelength. The near infra-red (NIR) region is more appealing for applications in tissue engineering, drug delivery or cosmetic as NIR has deeper penetration and less health hazard than UV. Short peptides however, have less pronounced existence in this field unless they are chemically modified with photo-responsive molecules that are reasoned to light between UV-NIR Here we are reporting an intrinsic behaviour of short peptide which upon two photon excitation shows dynamic behaviour that can be manipulated by adjusting laser intensity. The stability of peptide upon exposure to laser was probed with LCMS, HRMS and CD